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Advanced Liposomal Technology

The History of Liposome

Liposome research has expanded considerably over the last 30 years and nowadays, it is possible to construct a wide range of liposomes varying in size, phospholipids composition and surface characteristics to suit the specific application for which they are intended.The History of  Liposomes are vesicles consisting of spherical phospholipid bi-layers with specific properties making them useful for topical application of drugs. Liposomes help in reducing skin irritation by sustaining the release of drugs and by hydration of the epidermis. They may improve stabilization of instable drugs by encapsulating them and serve as penetration enhancers facilitating the transport of compounds that otherwise cannot penetrate the skin. Liposomes can be used as carriers for hydrophilic as well as lipophilic therapeutic agents because of their amphipathic character. In dermatology, the topical application of liposomes has proven to be of therapeutic value.


Liposome Technology In Skin Care

"This time we use a new method, and once and for all we establish that intact liposomes cannot penetrate the skin's surface. Therefore, we need to revise the way we perceive liposomes -- especially in the skin care industry, where liposomes are perceived as protective spheres transporting agents across the skin barrier, says Jonathan Brewer. It may well be that a chemical reaction starts, which somehow helps the agents travel through the skin barrier. They now recommend that science changes its focus towards these possible chemical reactions.

One can study their activity and the processes that occur at the molecular level, and this provides a valuable insight into how cells function.Many cosmetic companies praise liposomes for their alleged ability to transport juvinating and nourishing agents deep into the skin, but also drug researchers have high hopes for liposomes: If they can carry nourishing agents through the skin, then they can also carry medical agents into the body.

But now a new study from University of Southern Denmark finds that liposomes cannot penetrate the skin's barrier without breaking. However, the liposomes may in fact in some way help the agents get underway. So in a way you could say that the liposomes might work -- but then it is in a different way than the beauty industry tells us, the researchers said.

The study follows a previous study from 2013, in which the research team showed that liposomes lose their cargo of agents the moment they meet the skin's surface. "When the liposomes hit the skin and break, it is not certain that the active agents are wasted. The research group is the first in the world to use a special microscope, called a nanoscope, to study the skin. The studies have revealed that liposomes cannot carry active agents into the skin.

The study is published in the journal Plos One. With this technique it is possible to directly see the individual molecules and liposomes. The authors include postdoc Jes Dreier and Associate Professor Jonathan Brewer from the Department of Biochemistry and Molecular Biology, University of Southern Denmark.